Simultaneous Identification of Multiple Driver Pathways in Cancer
نویسندگان
چکیده
منابع مشابه
Simultaneous Identification of Multiple Driver Pathways in Cancer
Distinguishing the somatic mutations responsible for cancer (driver mutations) from random, passenger mutations is a key challenge in cancer genomics. Driver mutations generally target cellular signaling and regulatory pathways consisting of multiple genes. This heterogeneity complicates the identification of driver mutations by their recurrence across samples, as different combinations of muta...
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Distinguishing the somatic mutations responsible for cancer (driver mutations) from random, passenger mutations is a key challenge in cancer genomics. Driver mutations generally target cellular signaling and regulatory pathways consisting of multiple genes. This heterogeneity complicates the identification of driver mutations by their recurrence across samples, as different combinations of muta...
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Identification of genomic patterns in tumors is an important problem, which would enable the community to understand and extend effective therapies across the current (tissue-based) tumor boundaries. In this work, we make two specific contributions. First, we develop a robust system to discover cancer driver genes, via an unsupervised clustering of similarly expressed genes across cancer patien...
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Next-generation sequencing studies on cancer somatic mutations have discovered that driver mutations tend to appear in most tumor samples, but they barely overlap in any single tumor sample, presumably because a single driver mutation can perturb the whole pathway. Based on the corresponding new concepts of coverage and mutual exclusivity, new methods can be designed for de novo discovery of mu...
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ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2013
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1003054